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The Spinneret
Spring 2022

A Quarterly Newsletter from ramé-hart devoted to Coaxial, Triaxial, Quadaxial and Custom
Spinnerets used for Electrospinning, Bioprinting and Related Applications


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Leaders in Coaxial Bioprinting

You are probably already aware that ramé-hart is the world leader in custom spinnerets - including coaxial, triaxial, and even quadaxial designs. Traditionally, these spinnerets are used for electrospraying applications. However, another market that we serve which has been expanding rapidly in the past few years is coaxial bioprinting.

Coaxial bioprinting is essentially 3D printing using a coaxial nozzle to produce core-sheath fibers or extrusions. Different biomaterials can be used in the inner and outer channels in order to optimize the target properties. This novel technique enables a wide variety of possible combinations which gives researchers even more control over developing successful living constructs.

We share with you a select list of companies that are engaged in the development of coaxial bioprinting and who have partnered with ramé-hart for the production of custom coaxial dispensing nozzles - the majority of which are custom made.

Brinter specializes in bioprinting hardware used by cancer researchers to fabricate complex three-dimensional tumors in vitro. It's even possible to bioprint a tumor using a patient's own cancer cells. Other applications include tools for chrondral repairment and drug formulation development.

Brinter 3D Bioprinter

RegenHU is working on the complex task of producing human skin through an automated three-dimensional software-guided fabrication process. A coaxial micro-extrusion-based 3D printing method is being developed by Dutch and Swiss researchers using RegenHU hardware to produce personalized bone substitutes using a calcium phosphate ink.1 Rice University2 is one of many educational institutions that is using RegenHu hardware to 3D print complex tissue constructs using coaxial bioprinting methods.

CELLINK is a world leader in the bio-convergence revolution (which combines the power of biology, engineering, and computer science to create novel solutions in healthcare). CELLINK bioprinters use biomaterials such as hydrogels, cells, sacrificial material, and crosslinking solutions to produce a wide variety of solid, hollow, and composite three-dimensional structures.3

CELLINK Bio X6 Bioprinter with Coaxial Printhead

3DBio is a biotech startup focused on using 3D bioprinting to produce functional and personalized living tissue. Currently, they are working on treating Microtia, a congenital deformity of the outer ear as well as other custom-engineered living implants made using 3D bioprinting techniques.

Allevi, which is now a subsidiary of 3D Systems, is a pioneer in bioprinting. Their bioprinting hardware is being used by researchers working on organ-on-chip research, biomaterial development, pharmaceutical validation and regenerative medicine. Both the Allevi 2 and Allevi 3 bioprinters support coaxial 3D bioprinting. Researchers at Harvard, for example, use Allevi hardware to study the fabrication of human tissues and organs using a coaxial vertical embedded extrusion technique.4

Allevi Bioprinter with Coaxial Nozzle Installed

3D Systems, even prior to their acquisition of Allevi, was a leader in bioprinting. Their Our Print to Perfusion product allows 3D bioprinting of large, vascularized hydrogel scaffolds which can be perfused with living cells in order fabricate tissue. They also specialize in 3D Bioprinting of dental fixtures and teeth.

EDmicBio has developed a 3D bioprinting system that can be used for tissue and organ as well as 3D organ-on-a-chip fabrication. They have also developed a biodegradable vascular scaffold (called BODES) which replaces a metal stent and can be used to open a blocked blood vessel but then dissolves in the blood and disappears.

Organovo specializes in fabricating human tissues using their 3D bioprinting technology. This includes synthetic skin, kidney, and liver tissue. They design normal tissues as well as tissues for addressing disease.

Advanced Solutions Life Sciences focuses on robotic and vascular platforms for fabricating human tissues. They combine 3D bioprinting with robotic control to build biological structures. Their BioAssemblyBot product employs a four or six-axis robotic arm with a variety of tools to bioprint, pick up biological material, and build complex assays.

EnvisionTEC is the original inventor of digital light processing (DLP) 3D printing technology. While their product lineup includes a number of industrial 3D printing platforms, they also have a product called the 3D Bioplotter which features multiple print heads, sterilized heating and cooling cartridges and a heated platform for both cell and organ printing.

Poietis proposes a 4D bioprinting approach. The fourth D is a time element that involves analyzing tissue evolution during maturation which allows for optimization of tissue architecture via software. They are also developing laser-assisted bioprinting which aims to increase resolution. Their technology has been used to fabricate full thickness human skin. They have added or are working on adding AI (Artificial Intelligence) processing, robotics, online sensors, in-line monitoring, and computer-assisted design (CAD) capabilities to their line of bioprinters.

Nanofiber Solutions is focused on the production of engineered tissue such as scaffolds and grafts and nanofiber implants. Their platform is designed to mimic the environment found  in a living human body in order to improve outcome. They also manufacture cell culture plates used in drug discovery, research and pharmaceutical labs.

The regenerative medicine market is expanding at a brisk pace. Our short list above highlights the leaders in this field. But there are numerous other companies that are working on 3d bioprinting solutions. Among these are Aspect Biosystems, Printivo, Rokit, Prellis, Collplant, Spinsplit, and SKE Research Equipment, to name a few of many.

If you are involved in 3D bioprinting and wish to explore coaxial bioprinting, please contact us to learn more about our prebuilt and custom made coaxial nozzles. We specialize in special orders.

1 See doi:10.1016/j.actbio.2021.02.022.
2 See link.
3 Check out this video which shows the CELLINK BIO X6 doing some coaxial bioprinting.
4 See doi.org/10.1002/adhm.202102411.


Coupon Savings

Here are some ways to save on your next spinneret order:

1. Free Shipping to any address in the world. Order one or more prebuilt or custom coaxial, triaxial, or quadaxial spinneret and your shipping will be free to any address in the world. Simply use coupon code FREESHIP2022 during check out at https://www.ramehart.us/coaxial-needles/. Limit one use per customer. Cannot be combined with other offers. Valid until 1-July-2022. Valid for online orders paid with a credit card only.

2. Save $150. Order any three or more spinnerets, prebuilt or custom, and get a $150 off your order. Use coupon code SAVE150 during checkout at http://www.ramehart.us/coaxial-needles/. Limit one use per customer. Cannot be combined with other offers. Valid until 1-July-2022. Valid for online orders paid with a credit card only.

3. If you are purchasing 5 or more prebuilt or custom spinnerets, please contact us for information on our volume discounts.

Thank you for your continued business.


Carl Clegg
Director of Sales
Phone 973-448-0305
Contact us



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